https://erinjengelsonphd.com/researcharticles daily 0.75 2022-07-29 https://erinjengelsonphd.com/researcharticles/intermittent-fasting-and-weight-loss-systematic-review monthly 0.5 2022-07-30 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1659135345145-EYBP65K4D1WEK0L6Y47G/unsplash-image-5ddH9Y2accI.jpg researcharticles - Intermittent fasting and weight loss: Systematic review - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://erinjengelsonphd.com/researcharticles/high-throughput-single-microbe-genomics-with-strain-resolution-applied-to-a-human-gut-microbiome monthly 0.5 2022-06-08 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/cee9b461-36ca-43a5-9879-a547b866c781/science.abm1483-f5.jpg researcharticles - High-throughput, single-microbe genomics with strain resolution, applied to a human gut microbiome - Make it stand out Fig. 5. Host-phage association with strain specificity in the human gut microbiome. (A) Association between the bacteriophage crAssphage and bacterial species with high- or medium-quality genomes, with species numbers as in Fig. 2. All P values are calculated with one-sided Fisher’s exact test. The only bacterial species that is significantly associated with crAssphage is B. vulgatus. (B) Association between the four strains of B. vulgatus and crAssphage. Only one specific strain of B. vulgatus—the most abundant strain, A—is significantly associated with crAssphage. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/c5d95a03-2873-4477-b78c-73d8f60c951b/science.abm1483-f1.jpg researcharticles - High-throughput, single-microbe genomics with strain resolution, applied to a human gut microbiome - Make it stand out Fig. 1. Schematic of the Microbe-seq workflow and application in a community of known bacterial strains. (A) Schematic of the Microbe-seq workflow. Microbes are isolated by encapsulation with lysis reagents into droplets. Each microbe is lysed to liberate its DNA; after lysis, amplification reagents are added to each droplet to amplify the single-microbe genome within each. Tagmentation reagents are added into each droplet to fragment amplified DNA and tag them with adapters. PCR reagents and a bead with DNA barcodes are added to each droplet. PCR is performed to label the genomic materials with these primers, and droplets are broken to pool barcoded single-microbe DNA together. (B) Purity distribution of all SAGs from the mock community sample, which for a large majority of SAGs exceeds 95%, demonstrating single-microbe origin for the DNA in each of these SAGs. (C) Combined genome coverage of reads as a function of the number of SAGs from which these reads originate; error bars denote standard deviation. The dashed horizontal line indicates a coverage of 90%. In all cases, a few dozen SAGs contain essentially all the information of the microbial genome. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/5647b540-eea6-4f7a-b2f6-56089ae138cc/science.abm1483-f2.jpg researcharticles - High-throughput, single-microbe genomics with strain resolution, applied to a human gut microbiome - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/312db640-86fe-4a0d-a2c1-4de4fda46402/science.abm1483-f3.jpg researcharticles - High-throughput, single-microbe genomics with strain resolution, applied to a human gut microbiome - Make it stand out Fig. 3. Strain-resolved genomes of B. vulgatus in the human gut microbiome. (A) Dimension-reduction (UMAP) visualization of B. vulgatus SAGs, based on comparison of their sequences at SNP locations. SAGs fall into four distinct, widely separated clusters; the symbol for each SAG is colored according to the cluster in which it is grouped. (B) Scatterplot and histograms illustrating the fraction of SNPs from each SAG that match consensus genotypes for SAGs in the two most abundant clusters, A and B. In almost all cases, each SAG shares the same base in more than 99% of the SNP locations in its corresponding consensus genotype; by contrast, the SNP overlap with the consensus genotype of the other cluster is much lower, typically 5% or less. The symbols in each cluster are colored as in (A). (C) Phylogeny of the coassembled high- and medium-quality genomes of B. vulgatus strains and comparison with the corresponding genomes of strains of isolates cultured from the same human donor. The horizontal axis of the dendrogram represents the ANI values between these strain-resolved genomes, demonstrating that coassembled strain C and isolate S1 are the same strain; similarly, coassembled strain A and isolate S2 are the same strain. By contrast, the second most-abundant strain, B, does not appear among the isolates cultured from the same human donor. (D) Relative abundance of the four B. vulgatus strains in the seven longitudinal samples. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/4b7d1ac6-7a9a-49d8-a8b9-a5529f34b9e0/science.abm1483-f4.jpg researcharticles - High-throughput, single-microbe genomics with strain resolution, applied to a human gut microbiome - Make it stand out Fig. 4. HGT among bacterial strains within the human gut microbiome of a single donor. (A) HGT among the 49 species with a single high-quality strain-resolved genome, following the order, numbers, and colors of Fig. 2. Detected HGT between two genomes indicated with a curve whose color matches that of the phylum of each species pair. (B) HGT between species with multiple high-quality strain-resolved genomes and species with single high-quality strain-resolved genomes, following the numbering in (A). For the bacteria in phylum Firmicutes (Agathobacter faecis, Faecalicatena faecis, and Anaerostipes hadrus), each strain has HGT with different sets of species. For the phylum Bacteroidetes, the only multistrain species is B. vulgatus, which has HGT between both of its strains and all other species in this phylum. (C) Distribution of the number of species in which HGT genes are shared. Approximately half of the genes in these HGT sequences are shared among more than two species; several genes occur in six or seven bacterial strains. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/5647b540-eea6-4f7a-b2f6-56089ae138cc/science.abm1483-f2.jpg researcharticles - High-throughput, single-microbe genomics with strain resolution, applied to a human gut microbiome - Make it stand out Fig. 2. Coassembled genomes of 76 bacterial species in the human gut microbiome of a single human donor. These 76 bacterial species have high- or medium-quality coassembled genomes. A phylogeny constructed from ribosomal protein sequences is represented by the dendrogram in the center of the circle. The phylum of each species is indicated by the background color behind each listed species name (GTDB-Tk database); the 19 species with genomes from isolates cultured from the same human donor are marked with an asterisk. The number of SAGs used for coassembly (abundance) is indicated by the bars in the outermost ring, shaded in gray for the 52 high-quality genomes and unshaded for the 24 medium-quality genomes. https://erinjengelsonphd.com/researcharticles/the-ugt2a1ugt2a2-locus-is-associated-with-covid-19-related-loss-of-smell-or-taste monthly 0.5 2022-06-07 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/0d6f53ba-1a63-4989-b6f6-e7a394923b2e/41588_2021_986_Fig1_HTML.png researcharticles - The UGT2A1/UGT2A2 locus is associated with COVID-19-related loss of smell or taste - Make it stand out a, Manhattan plot. SNPs achieving genome-wide significance are highlighted in red. The nearest gene to the index SNP is indicated above the relevant association peak. b, Regional plot around the UGT2A1/UGT2A2 locus. The colors indicate the strength of linkage disequilibrium (r2) relative to the index SNP (rs7688383). Imputed variants are indicated with ‘+’ symbols; coding variants are indicated with ‘x’ symbols. Where imputed variants were not available, directly genotyped variants are indicated by ‘o’ symbols; coding variants are indicated by diamond symbol https://erinjengelsonphd.com/researcharticles/protection-of-bnt162b2-vaccine-booster-against-covid-19-in-israel monthly 0.5 2021-09-25 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1632601178893-LKVGPPF06L9T1FCG09BW/Figure+2.png researcharticles - Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel - Make it stand out Figure 2. Reduction in Rate of Confirmed Infection in Booster Group as Compared with Nonbooster Group. Shown is the factor reduction in the rate of confirmed infection among participants who received a third (booster) dose of the BNT162b2 vaccine as compared with those who did not receive a booster dose, according to the number of days after the administration of the booster dose. Because of wide confidence intervals, only days 1 through 25 are shown. The dashed horizontal line represents the level at which the booster dose provided no added protection. The bars represent 95% confidence intervals, which have not been corrected for multiplicity. https://erinjengelsonphd.com/researcharticles/safety-and-efficacy-of-single-dose-ad26cov2s-vaccine-against-covid-19 monthly 0.5 2021-04-24 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1619299190191-8NT44CXZ0NN61F0M8A5B/Ad26.COV2.S+Death+curve.jpg researcharticles - Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19 Figure 2. Cumulative Incidence of Covid-19 with Onset at Least 1 Day after Vaccination and Vaccine Efficacy over Time. Panel A shows the cumulative incidence of moderate to severe–critical cases of coronavirus disease 2019 (Covid-19); circles indicate severe–critical cases. Panel B shows the cumulative incidence of severe–critical cases. Cases included in the analyses in Panels A and B were centrally confirmed cases in the full analysis set among participants who were seronegative at baseline. Panel C shows the cumulative incidence of severe–critical cases in South Africa among participants who were seronegative at baseline; these cases were those that were positive on reverse-transcriptase–polymerase-chain-reaction (RT-PCR) testing from all sources, whether centrally confirmed or not. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1619201589451-LL580IB0AGC7CRB188TC/nejmoa2101544_f1.jpeg researcharticles - Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19 Figure 1. Solicited Local and Systemic Adverse Events Reported within 7 days after the Administration of Vaccine or Placebo (Safety Subpopulation). Most solicited local and systemic adverse events occurred within 1 to 2 days after the administration of vaccine or placebo and had a median duration of 1 to 2 days. No grade 4 local or systemic adverse events were reported. There were no local or systemic reactogenicity differences between participants who were seronegative at baseline and those who were seropositive (data not shown). Pain was categorized as grade 1 (mild; does not interfere with activity), grade 2 (moderate; requires modification of activity or involves discomfort with movement), grade 3 (severe; inability to perform usual activities), or grade 4 (potentially life-threatening; hospitalization or inability to perform basic self-care). Erythema and swelling were categorized as grade 1 (mild; 25 to 50 mm), grade 2 (moderate; 51 to 100 mm), grade 3 (severe; >100 mm), or grade 4 (potentially life-threatening; necrosis or leading to hospitalization). Systemic events were categorized as grade 1 (mild; minimal symptoms), grade 2 (moderate; notable symptoms not resulting in loss of work or school time), grade 3 (severe; incapacitating symptoms resulting in loss of work or school time), or grade 4 (life-threatening; hospitalization or inability to perform basic self-care). Fever was defined as grade 1 (mild; ≥38.0 to 38.4°C), grade 2 (moderate; ≥38.5 to 38.9°C), grade 3 (severe; ≥39.0 to 40.0°C), or grade 4 (potentially life-threatening; >40°C). https://erinjengelsonphd.com/researcharticles/model-informed-covid-19-vaccine-prioritization-strategies-by-age-and-serostatus monthly 0.5 2021-01-24 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1611454559625-YSOAYYQCR76XOVVIIGZS/F4.large.jpg researcharticles - Model-informed COVID-19 vaccine prioritization strategies by age and serostatus Figure 4 Effects of existing seropositivity on the impacts of prioritization strategies. Percent reductions in (A) infections, (B) deaths, and (C) years of life lost (YLL) for prioritization strategies when existing age-stratified seroprevalence is incorporated [August 2020 estimates for New York City; mean seroprevalence 26.9% (27)]. Plots show reductions for Scenario 2 (0.2% rollout/day, R0 = 1.5) when vaccines are given to all individuals (solid lines) or to only seronegatives (dashed lines), inclusive of 96% serotest sensitivity, 99% specificity (53), and approximately three months of seroreversion (supplementary materials, materials and methods) (29). Shown: U.S. contact patterns and demographics (37, 52); all-or-nothing and transmission-blocking vaccine with 90% vaccine efficacy. See figs. S12 and S13 for lower and higher seroprevalence examples, respectively. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1611453413457-OMSQDEVTSGXG7Q98OQ61/F1.large.jpg researcharticles - Model-informed COVID-19 vaccine prioritization strategies by age and serostatus Figure. 1 Impacts of vaccine prioritization strategies on mortality and infections. (A) Distribution of vaccines for five prioritization strategies: under 20, adults 20-49, adults 20+, adults 60+ and all ages. (B and C) Example simulation curves show percentage of the total population infected over time and (F and G) cumulative mortality for no vaccines (grey dashed lines) and for five different prioritization strategies [colored lines matching (A)], with 10% [(B) and (F)] and 30% [(C) and (G)] vaccine supply. Summary curves show percent reductions in (D and E) infections and (H and I) deaths in comparison to an unmitigated outbreak for vaccine supplies between 1% and 50% after 365 days of simulation. Squares and diamonds show how the outputs from single simulations [(F) and (G)] correspond to points in summary curves (H). Grey shading indicates period during which vaccine is being rolled out at 0.2% of total population per day. Black dots indicate breakpoints at which prioritized demographic groups have been 70% vaccinated, after which vaccines are distributed without prioritization. These simulations assume contact patterns and demographics of the United States (37, 52) and an all-or-nothing, transmission-blocking vaccine with 90% vaccine efficacy and R0 = 1.5) (Scenario 2) and (R0 = 1.15) (Scenario 1). https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1611454256515-W9VFTGIIFU0CBIDCJNAS/F2.large.jpg researcharticles - Model-informed COVID-19 vaccine prioritization strategies by age and serostatus Figure. 2 Mortality-minimizing vaccine prioritization strategies across reproductive numbers R0 and countries. Heatmaps show the prioritization strategies resulting in maximum reduction of mortality for varying values of the basic reproductive number R0 (A and B) and across nine countries (C, D, and E), for vaccine supplies between 1% and 50% of the total population, for an all-or-nothing and transmission blocking vaccine, 90% vaccine efficacy. (A, B) Shown: contact patterns and demographics of the United States (37, 52); [(C), (D), and (E)] Shown: contact patterns and demographics of POL, Poland; ZAF, South Africa; CHN, China; BRA, Brazil; ZWE, Zimbabwe; ESP, Spain; IND, India; USA, United States of America; BEL, Belgium, with R0 and rollout speeds as indicated. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1611454398876-5M4IQQ7JY3VNGHGK8NP5/F3.large.jpg researcharticles - Model-informed COVID-19 vaccine prioritization strategies by age and serostatus Figure. 3 Effects of age-dependent vaccine efficacy on the impacts of prioritization strategies. (A) Diagram of hypothetical age-dependent vaccine efficacy shows decrease from 90% baseline efficacy to 50% efficacy among individuals 80+ beginning at age 60 (dashed line). (B and C) Percent reduction in deaths in comparison to an unmitigated outbreak for transmission-blocking all-or-nothing vaccines with either constant 90% efficacy for all age groups (solid lines) or age-dependent efficacy shown in (A) (dashed lines), covering Scenario 1 [0.2% rollout/day, R0 = 1.15; (B)] and Scenario 2 [0.2% rollout/day, R0 = 1.5 (C)]. Black dots indicate breakpoints at which prioritized demographic groups have been 70% vaccinated, after which vaccines are distributed without prioritization. Shown: contact patterns and demographics of the United States (37, 52); all-or nothing and transmission blocking vaccine. https://erinjengelsonphd.com/researcharticles/genomic-epidemiology-of-superspreading-events-in-austria-reveals-mutational-dynamics-and-transmission-properties-of-sars-cov-2 monthly 0.5 2021-01-11 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1610337534369-K2B5FQ1NNT86PV86YGU0/F5.large.jpg researcharticles - Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2 Fig. 5 Impact of transmission bottlenecks and intrahost evolution on SARS-CoV-2 mutational dynamics. (A) Schematics of time-related patient interactions across epidemiological clusters A and AL. Each node represents a case, and links between the nodes are epidemiologically confirmed direct transmissions. Samples sequenced from the same individual are reported under the corresponding node. Cases corresponding to the same family are color coded accordingly. Additional families, unrelated to clusters A/AL, and their epidemiological transmission details are also reported. (B) Bottleneck size (number of virions that initiate the infection in an infectee) estimation across infector-infectee pairs based on the transmission network depicted in (A), ordered according to the timeline of cluster A for the respective pairs, and with a cutoff of [0.01, 0.95] for alternative allele frequency. For patients with multiple samples, the earliest sample was considered for bottleneck size inference. Centered dots are maximum likelihood estimates, with 95% confidence intervals. A star (*) for family 4 indicates that the transmission line was inferred as detailed in Materials and Methods. The histogram (yellow bars) of all the bottleneck values is provided on the right side of the graph. (C) Alternative allele frequency (y axis) of mutations across available time points (x axis) for patient 5. Only variants with frequencies ≥0.02 and shared between at least two time points are shown. Two mutations increasing in frequency are color coded. (D) Genetic distance values of mutation frequencies between infector-infectee pairs (A and B) (transmission chains) and intrapatient consecutive time points [(C) and fig. S5D]. Only variants detected in two same-patient samples were considered. https://erinjengelsonphd.com/researcharticles/efficacy-and-safety-of-the-mrna-1273-sars-cov-2-vaccine monthly 0.5 2021-01-05 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1609792719962-7BJ3VJ1HCS9STBLI7GTI/nejmoa2035389_t1.jpeg researcharticles - Efficacy and Safety of the MRNA-1273 SARS-CoV-2 Vaccine Table 1. Demographic Characteristics of the Participants in the Main Safety Population. https://erinjengelsonphd.com/researcharticles/safety-and-efficacy-of-the-bnt162b2-mrna-covid-19-vaccine monthly 0.5 2021-01-02 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1609618241131-0HGPRWYRJAIW5YSNKZDZ/NEJMoa2034577_f2.jpg researcharticles - Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine Figure 2. Local and Systemic Reactions Reported within 7 Days after Injection of BNT162b2 or Placebo, According to Age Group. Data on local and systemic reactions and use of medication were collected with electronic diaries from participants in the reactogenicity subset (8,183 participants) for 7 days after each vaccination. Solicited injection-site (local) reactions are shown in Panel A. Pain at the injection site was assessed according to the following scale: mild, does not interfere with activity; moderate, interferes with activity; severe, prevents daily activity; and grade 4, emergency department visit or hospitalization. Redness and swelling were measured according to the following scale: mild, 2.0 to 5.0 cm in diameter; moderate, >5.0 to 10.0 cm in diameter; severe, >10.0 cm in diameter; and grade 4, necrosis or exfoliative dermatitis (for redness) and necrosis (for swelling). Systemic events and medication use are shown in Panel B. Fever categories are designated in the key; medication use was not graded. Additional scales were as follows: fatigue, headache, chills, new or worsened muscle pain, new or worsened joint pain (mild: does not interfere with activity; moderate: some interference with activity; or severe: prevents daily activity), vomiting (mild: 1 to 2 times in 24 hours; moderate: >2 times in 24 hours; or severe: requires intravenous hydration), and diarrhea (mild: 2 to 3 loose stools in 24 hours; moderate: 4 to 5 loose stools in 24 hours; or severe: 6 or more loose stools in 24 hours); grade 4 for all events indicated an emergency department visit or hospitalization. bars represent 95% confidence intervals, and numbers above the bars are the percentage of participants who reported the specified reaction. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1609618088208-76VVGT7X4QRAY8K7WG46/NEJMoa2034577_f1.jpg researcharticles - Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine Figure 1. Enrollment and Randomization. The diagram represents all enrolled participants through November 14, 2020. The safety subset (those with a median of 2 months of follow-up, in accordance with application requirements for Emergency Use Authorization) is based on an October 9, 2020, data cut-off date. The further procedures that one participant in the placebo group declined after dose 2 (lower right corner of the diagram) were those involving collection of blood and nasal swab samples. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1609616365911-Q04TXN3TSZNB0ZO5IWJT/NEJMoa2034577_f3.jpg researcharticles - Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine Figure 3. Efficacy of BNT162b2 against Covid-19 after the First Dose. Shown is the cumulative incidence of Covid-19 after the first dose (modified intention-to-treat population). Each symbol represents Covid-19 cases starting on a given day; filled symbols represent severe Covid-19 cases. Some symbols represent more than one case, owing to overlapping dates. The inset shows the same data on an enlarged y axis, through 21 days. Surveillance time is the total time in 1000 person-years for the given end point across all participants within each group at risk for the end point. The time period for Covid-19 case accrual is from the first dose to the end of the surveillance period. The confidence interval (CI) for vaccine efficacy (VE) is derived according to the Clopper–Pearson method. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1609619130754-S6MA53HBCZ8XNHP0F9CI/NEJMoa2034577_f3.jpg researcharticles - Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine Figure 3. Efficacy of BNT162b2 against Covid-19 after the First Dose. Shown is the cumulative incidence of Covid-19 after the first dose (modified intention-to-treat population). Each symbol represents Covid-19 cases starting on a given day; filled symbols represent severe Covid-19 cases. Some symbols represent more than one case, owing to overlapping dates. The inset shows the same data on an enlarged y axis, through 21 days. Surveillance time is the total time in 1000 person-years for the given end point across all participants within each group at risk for the end point. The time period for Covid-19 case accrual is from the first dose to the end of the surveillance period. The confidence interval (CI) for vaccine efficacy (VE) is derived according to the Clopper–Pearson method. https://erinjengelsonphd.com/researcharticles/direct-evidence-for-infection-of-varroa-destructor-mites-with-the-bee-pathogenic-deformed-wing-virus-variant-b-but-not-variant-a-via-fluorescence-in-situ-hybridization-analysis monthly 0.5 2020-12-27 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1609037962705-GBQO8PADEQSXYS5CHIOM/ticker_ss_beevirus+mite.jpg researcharticles - Direct evidence for infection of Varroa destructor mites with the bee-pathogenic deformed wing virus variant B - but not variant A - via fluorescence-in situ hybridization analysis. https://erinjengelsonphd.com/researcharticles/a-ubiquitous-tire-rubberderived-chemical-induces-acute-mortality-in-coho-salmon monthly 0.5 2020-12-04 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1607120752291-5R7GAGM7YQPVM6CB49IW/F3.large.jpg researcharticles - A ubiquitous tire rubber–derived chemical induces acute mortality in coho salmon https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1607100679742-CSHNY8KA1F1ZSGYX6MI7/F4.large+Salmon+6PPD.jpg researcharticles - A ubiquitous tire rubber–derived chemical induces acute mortality in coho salmon Figure 4 Environmental relevance of 6PPD-quinone. (A) Using retrospective UPLC-HRMS analysis of archived sample extracts, 6PPD-quinone was quantified in roadway runoff and runoff-impacted receiving waters. Each symbol corresponds to duplicate or triplicate samples, boxes represent first and third quartiles. For comparison, the 0.8 μg/L LC50 value for juvenile coho salmon and detected 6PPD-quinone levels in 250 and 1000 mg/L TWP leachate are included. (B) Predicted ranges of potential 6PPD-quinone mass formation in passenger cars (e.g., 4 tires, ~36 kg tire rubber mass) and heavy trucks, (e.g., 18 tires, ~900 kg of tire rubber) (represented in orange) and measured 6PPD-quinone concentrations in affected environmental compartments (represented in blue, with experimental data italicized). Predicted ranges reflect calculations applying 0.4-2% 6PPD per total vehicle tire rubber mass followed by various yield scenarios (1-75% ultimate yields) for 6PPD reaction with ground-level ozone to form 6PPD-quinone. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1607120597206-QWU4AKQRJ09Y8DNKM6NX/F2.large.jpg researcharticles - A ubiquitous tire rubber–derived chemical induces acute mortality in coho salmon Figure 2 6PPD-quinone identification and a proposed formation pathway. (A) Extracted ion chromatograms of 6PPD-quinone from UPLC-HRMS (ESI+); red data represents the final fraction from TWP leachate, while black data represents the purified 6PPD ozonation mixture. (B) Observed MS/MS fragmentation (integrated from 10, 20, 40 eV) of 6PPD-quinone in the final toxic fraction from TWP leachate (red spectra) and 6PPD ozonation (black spectra). (C) One proposed reaction pathway from 6PPD to 6PPD-quinone (see fig. S13 for alternate proposed formation pathways). Red highlights detail key changes in the diphenylamine structure during ozonation. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1607120456747-6367NTF0QK2DRPOD21S4/F1.large.jpg researcharticles - A ubiquitous tire rubber–derived chemical induces acute mortality in coho salmon Figure 1 Tire rubber leachate fractionation scheme. As a metric of mixture complexity and separation efficiency, the numbers above gray bars represent unique chemical features detected in solid-phase extracted fish exposure water (1 L) and subsequent fractions by UPLC-HRMS. Blue colors represent non-lethal fractions; red colors represent lethal fractions. All fractionation steps and exposures were replicated at least twice; positive and negative controls were included throughout fractionations. The inset photo depicts purified product (~700 μg from 30 L of TWP leachate) in the final lethal fraction. TWP, tire tread wear particles; CEX, cation exchange; EA, ethyl acetate; EtOH, ethanol; H2O, water; Hex, hexane; DCM, dichloromethane; RT, retention time. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1607120865264-KS9M1X0273JJ8LDXQ7X6/F4.large.jpg researcharticles - A ubiquitous tire rubber–derived chemical induces acute mortality in coho salmon Figure 4 Environmental relevance of 6PPD-quinone. (A) Using retrospective UPLC-HRMS analysis of archived sample extracts, 6PPD-quinone was quantified in roadway runoff and runoff-impacted receiving waters. Each symbol corresponds to duplicate or triplicate samples, boxes represent first and third quartiles. For comparison, the 0.8 μg/L LC50 value for juvenile coho salmon and detected 6PPD-quinone levels in 250 and 1000 mg/L TWP leachate are included. (B) Predicted ranges of potential 6PPD-quinone mass formation in passenger cars (e.g., 4 tires, ~36 kg tire rubber mass) and heavy trucks, (e.g., 18 tires, ~900 kg of tire rubber) (represented in orange) and measured 6PPD-quinone concentrations in affected environmental compartments (represented in blue, with experimental data italicized). Predicted ranges reflect calculations applying 0.4-2% 6PPD per total vehicle tire rubber mass followed by various yield scenarios (1-75% ultimate yields) for 6PPD reaction with ground-level ozone to form 6PPD-quinone. https://erinjengelsonphd.com/researcharticles/infectious-disease-bulletin-from-infectious-disease-expert-contributors monthly 0.5 2021-02-24 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1606450348205-Z1F42J09W5ZO36H0PHN2/image-asset.png researcharticles - False Negative Tests for SARS-CoV-2 Infection — Challenges and Implications https://erinjengelsonphd.com/researcharticles/molecular-architecture-of-early-dissemination-and-massive-second-wave-of-the-sars-cov-2-virus-in-a-major-metropolitan-area monthly 0.5 2020-11-27 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1605064417747-LQ3FNJ0FT5AX1DDPGRSI/F6.large+D+G.jpg researcharticles - Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area Location of amino acid substitutions mapped on the SARS-CoV-2 spike protein. The figure presents a model of the SARS-CoV-2 spike protein with one protomer shown as ribbons and the other two protomers shown as a molecular surface. The Cα atom of residues found to be substituted in one or more virus isolates identified in this study is shown as a sphere on the ribbon representation. Residues found to be substituted in 1 to 9 isolates are colored tan, those substituted in 10 to 99 isolates yellow, those substituted in 100 to 999 isolates red (H49Y and F1052L), and those substituted in >1,000 isolates purple (D614G). The surface of the amino-terminal domain (NTD) that is distal to the trimeric axis has a high density of substituted residues. RBD, receptor binding domain. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1605063309923-T4L3LUHTQ57XCY5XLW1G/F1.large+D614+G.jpg researcharticles - Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area (A) Confirmed COVID-19 cases in the Greater Houston Metropolitan region. Data represent cumulative number of COVID-19 patients over time through 7 July 2020. Counties include Austin, Brazoria, Chambers, Fort Bend, Galveston, Harris, Liberty, Montgomery, and Waller. The shaded area represents the time period (indicated as month/day along the x axis) during which virus genomes characterized in this study were recovered from COVID-19 patients. The red line represents the number of COVID-19 patients diagnosed in the Houston Methodist Hospital Molecular Diagnostic Laboratory. (B) Distribution of strains with either the Asp614 or Gly614 amino acid variant in spike protein among the two waves of COVID-19 patients diagnosed in the Houston Methodist Hospital Molecular Diagnostic Laboratory. The large inset shows major clade frequency for the time frame studied (indicated as month-day to month-day along the x axis). https://erinjengelsonphd.com/researcharticles/immune-responses-to-sars-cov-2-infection-in-hospitalized-pediatric-and-adult-patients monthly 0.5 2020-10-16 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1602878017719-S0IL5KCFA5V5RGDO3TG8/F5.large.jpg researcharticles - Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients Fig. 5 Neutralizing antibody titers in patient serum vary by age. (A) VSV-S was incubated with serial twofold dilutions of patient serum or culture media as a control for 1 hour at 37°C and subsequently was added to cultured Vero cell monolayers. Neutralization of VSV-S by antibody was measured after 48 hours by comparing reduction in plaque number relative to control wells. (B) A comparison of AUC for neutralizing antibody data in (A) for pediatric and adult patients. (C to E) Correlations between neutralizing antibody AUC and age in years (C) or serum concentrations of IFN-γ (D) and IL-17A (E) and age in years are presented. In (A), n = 8 per group; in (B), n = 16 per group. Data in (A) and (B) are presented as mean ± SD. Data in (B) were analyzed by unpaired Student’s t test. Correlations in (D) to (F) were determined by Spearman’s nonparametric correlation. *P < 0.05. https://erinjengelsonphd.com/researcharticles/2020-nobel-prize-in-physiology-or-medicine-announcement monthly 0.5 2020-10-05 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1601939304760-V9PDAD0CMMDCHEPYA8FM/Nobel+Prize+PM+2020+NOBEL02-superJumbo-v2.jpg researcharticles - 2020 Nobel Prize in Physiology or Medicine Announcement Photo Credit: New York Times, October 5, 2020 https://erinjengelsonphd.com/researcharticles/a-giant-planet-candidate-transiting-a-white-dwarf monthly 0.5 2020-09-17 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1600301467265-9VZNQ85RYDNVL7SZ7GUP/news+and+views+WD+1856.png researcharticles - A giant planet candidate transiting a white dwarf https://erinjengelsonphd.com/researcharticles/santa-ana-winds-of-southern-california-impact-pm-25-with-and-without-smoke-from-wildfires monthly 0.5 2020-09-11 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1599844777582-Z5QZDWESBB9NVPLG5NW1/Geohealth+2020+Figure+5.jpg researcharticles - Santa Ana Winds of Southern California Impact PM 2.5 With and Without Smoke From Wildfires Case study highlighting significant correlation between PM2.5 and wildfires. Daily gridded SAW vectors shown were obtained from Guzman‐Morales et al., 2016. (a) The Moderate Resolution Imaging Spectroradiometer Rapid Response System (https://lance.modaps.eosdis.nasa.gov/cgi-bin/imagery/gallery.cgi) satellite image shows the smoke plumes for fires burning on 22 October, and wind vectors represent wind velocity for that same day. High positive correlations are found in coastal zip codes, which remained with poor air quality conditions after (b) 2 weeks from the onset of the first wildfire. Fire perimeters display the total area burned and the date reflects the start of the fire. https://erinjengelsonphd.com/researcharticles/the-foundation-of-efficient-robot-learning monthly 0.5 2020-08-25 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1598371712632-W14TE2V7QWAD4KUEP6I9/The+foundation+of+efficient+robot+learning.gif researcharticles - The foundation of efficient robot learning General-purpose robots are being designed to help with domestic tasks. However, developing the learning applications needed to allow robots to undertake even simple tasks is extremely challenging. https://erinjengelsonphd.com/researcharticles/a-molecular-pore-spans-the-double-membrane-of-the-coronavirus-replication-organelle monthly 0.5 2020-08-11 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1597167979146-BZY2PX3OY4WDLJSGKHEW/Wolff+DMV+Fig+4.jpg researcharticles - A molecular pore spans the double membrane of the coronavirus replication organelle Figure 4 Model of the coronavirus genomic RNA transit from the DMV lumen to virus budding sites. (Top) Tomographic slices from MHV-infected cells highlighting the respective steps in the model (bottom). (A) The molecular pore exports viral RNA into the cytosol, (B) where it can be encapsidated by N protein. (C) Cytosolic RNPs then can travel to virus assembly sites for membrane association and (D) subsequent budding of virions. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1597167906981-F6WB45AK7ISJBYV0O6PL/Wolf+DMV+Fig+3.jpg researcharticles - A molecular pore spans the double membrane of the coronavirus replication organelle Figure 3 The coronavirus transmembrane-protein nsp3 is a component of the pore complex. (A) Membrane topology (top) of MHV transmembrane nsps with protease cleavage sites indicated by orange (PL1pro), red (PL2pro) and gray (Mpro) arrowheads. (bottom) Detailed depiction of nsp3, showing some of its sub-domains and the position of the additional GFP moiety that is present in MHV-Δ2-GFP3. (B) Tomographic slice of DMVs induced by MHV-Δ2-GFP3 with embedded pore complexes (white arrowheads). Comparison of the central slices of the 6-fold symmetrized subtomogram averages of the pore complexes in DMVs induced by (C) wt MHV and (D) MHV-Δ2-GFP3. (E) Density differences of 3 standard deviations between the mutant and the wt structures, shown as a green overlay over the latter, revealed the presence of additional (EGFP) masses in the mutant complex (black arrowheads, see also movie S3). PLpro, papain-like protease; Mpro, main protease. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1597167490567-NHDFE76CRL6090DSNHVQ/Wolff+DMV+cryo+ET+Fig+1.jpg researcharticles - A molecular pore spans the double membrane of the coronavirus replication organelle Figure 1 Coronavirus-induced DMVs revealed by cryo-ET. (A) Tomographic slice (7 nm thick) of a cryo-lamella milled through an MHV-infected cell at a middle stage in infection. (B) 3D model of the tomogram with the segmented content annotated, see also movie S1. ERGIC, ER-to-Golgi intermediate compartment; RNP, ribonucleoprotein complex. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1597167716710-7XFVRE34NB2DQFEX4A0V/Wolff+DMV+Fig+2.jpg researcharticles - A molecular pore spans the double membrane of the coronavirus replication organelle Figure 2 Architecture of the molecular pores embedded in DMV membranes. Tomographic slices (7 nm thick) revealed that pore complexes were present in both (A, inset) MHV-induced and (B) prefixed SARS-CoV-2-induced DMVs (white arrowheads). (C to L) 6-fold symmetrized subtomogram average of the pore complexes in MHV-induced DMVs. (C) Central slice through the average, suggesting the presence of flexible or variable masses near the prongs (black arrowhead) and on the DMV luminal side. (D to F) Different views of the 3D surface-rendered model of the pore complex (copper-colored) embedded in the outer (yellow) and inner (blue) DMV membranes. (G to M) 2D cross-section slices along the pore complex at different heights (see also movie S2). (M and N) An additional density at the bottom of the 6-fold symmetrized volume (c6, green) appeared as an off-centered asymmetric density in the unsymmetrized average (c1). https://erinjengelsonphd.com/researcharticles/brca1-brca2-pathogenic-variant-breast-cancer-treatment-and-prevention-strategies monthly 0.5 2020-07-28 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1595459679267-4028MBZQ76R846M4XTKS/Breast+Cancer+and+Genes+Mar+2020.jpg researcharticles - BRCA1/ BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies Figure 1: Incidence of breast cancer. (A) hereditary breast cancer accounts for 5–10% of all breast cancer cases. (B) BRCA1/BRCA2 pathogenic variant breast cancer accounts for up to 60% of all hereditary breast cancer cases [97]. Copyright permission for this figure was obtained from publisher. https://erinjengelsonphd.com/researcharticles/detection-of-crispr-adaptation-1 monthly 0.5 2020-07-19 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1594571506328-L7DKDHPNHR4EV224IZPZ/image-asset.jpeg researcharticles - Detection of CRISPR Adaptation https://erinjengelsonphd.com/researcharticles/telomere-length-correlates-with-subtelomeric-dna-methylation-in-long-term-mindfulness-practitioners monthly 0.5 2020-07-16 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1594851302006-2CTG1M4LI8KAV5KVTIE8/Meditation+Figure+1+2020.jpg researcharticles - Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners Relationships between intergenic (chr4: 1514317–1514621), GPR31, and SERPINB9 DNA methylation levels and telomere length, according to group. The intergenic region (chr4: 1514317–1514621) is in the first row, GPR31 in the second, and SERPINB9 in the third. Long-term meditators are in the first column and controls are in the second. Methylation levels are represented in the horizontal axis (X), and telomeres length in the vertical axis (Y). https://erinjengelsonphd.com/researcharticles/it-is-time-to-address-airborne-transmission-of-covid-19 monthly 0.5 2020-07-11 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1594245794420-QI9766OSD2YH7CM3D9P6/image-asset.jpeg researcharticles - It is Time to Address Airborne Transmission of COVID-19 https://erinjengelsonphd.com/researcharticles/the-emerging-spectrum-of-covid-19-neurology-clinical-radiological-and-laboratory-findings monthly 0.5 2020-07-08 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1594217683149-0Q0YDL0E68Y6O18V8N9O/Brain+2020+Zandi+Figure.jpg researcharticles - The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings Imaging from Patients 12, 13 and 15 (COVID-19 autoimmune and haemorrhagic encephalitis). Axial MRI from three individuals with para-/post-infectious central syndromes. (A–D) Patient 12: axial fluid-attenuated inversion recovery (FLAIR) images show bilateral hyperintensity in the mesial temporal lobes (A and B), hypothalamus (C) temporal lobes and thalamus (D). (E–H) Patient 13: axial T2-weighted (E), diffusion weighted imaging (DWI) (F), susceptibility weighted imaging (SWI) (G) and post-contrast T1-weighted (H) images show multifocal clusters of lesions involving the deep white matter of both cerebral hemispheres, intralesional cyst-like areas of varied sizes, and some peripheral rims of restricted diffusion (F), some haemorrhagic changes (G), and T1 hypointense ‘black holes’ without contrast enhancement (H). (I–P) Patient 15: axial images at the level of the insula and basal ganglia (I–L) and at the level of the temporal lobes and upper pons (M–P). T2-weighted images (I and M), SWI images (J and N), DWI images (K and O) and contrast-enhanced images (L and P). There are extensive confluent areas of T2 hyperintensity (I and M), with haemorrhagic change on SWI imaging (J and N), restricted diffusion on DWI images (K and O) and peripheral contrast-enhancement (arrows in L and P) in the insular region, basal ganglia and left occipital lobe (I–L) as well as in the medial temporal lobes and upper pons (M–P). https://erinjengelsonphd.com/researcharticles/the-airborne-lifetime-of-small-speech-droplets-and-their-potential-importance-in-sars-cov-2-transmission monthly 0.5 2020-07-07 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1594132652971-E367MD40XEFL4WSAJLLO/Figure+1+PNAS+respiratory+droplets.jpg researcharticles - The airborne lifetime of small speech droplets and their potential importance in SARS-CoV-2 transmission Light scattering observation of airborne speech droplet nuclei, generated by a 25-s burst of repeatedly speaking the phrase “stay healthy” in a loud voice (maximum 85 dBB at a distance of 30 cm; average 59 dBB). (A) Chart of particle count per frame versus time (smoothed with a 24-s moving average), with the red curve representing the top 25% in scattering brightness and the green curve representing the rest. The bright fraction (red) decays with a time constant of 8 min, and the dimmer fraction (green) decays with a time constant of 14 min. Both exponential decay curves return to their respective background level of ca. 0 (red horizontal dashed line) and 0.4 (green dashed line) counts per frame. Time “0” corresponds to the time the stirring fan was turned off. The 25-s burst of speaking started 36 s before time 0. The black arrow (at 0.5 min) marks the start of the exponential fits. (B) Image of the sum of 144 consecutive frames (spanning 6 s) extracted shortly after the end of the 25-s burst of speaking. The dashed circle marks the needle tip used for focusing the camera. The full movie recording is available in ref. 17, with time “0” in the graph at time point 3:38 in the movie. https://erinjengelsonphd.com/researcharticles/chloroquine-and-hydroxychloroquine-for-covid-19-a-word-of-caution monthly 0.5 2020-07-05 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1593967578993-Z8ZLULGSFYZ6H1DS00S0/image-asset.jpeg researcharticles - Chloroquine and Hydroxychloroquine for COVID-19: A Word of Caution https://erinjengelsonphd.com/researcharticles/prevalent-eurasian-avian-like-h1n1-swine-influenza-virus-with-2009-pandemic-viral-genes-facilitating-human-infection monthly 0.5 2020-07-01 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1593612047500-A9UZ0NN6KTYHSFSWODIU/genes+and+organisms+of+influenza.png researcharticles - Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection https://erinjengelsonphd.com/researcharticles/multiple-assays-in-a-real-time-rt-pcr-sars-cov-2-panel-can-mitigate-the-risk-of-loss-of-sensitivity-by-new-genomic-variants-during-the-covid-19-outbreak monthly 0.5 2020-06-28 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1593224136721-89DIOI6PKLJMZ8J0G807/SARS-CoV_2_Structure.jpg researcharticles - Multiple assays in a real-time RT-PCR SARS-CoV-2 panel can mitigate the risk of loss of sensitivity by new genomic variants during the COVID-19 outbreak https://erinjengelsonphd.com/researcharticles/lifting-the-lid-on-toilet-plume-aerosol-a-literature-review-with-suggestions-for-future-research monthly 0.5 2020-06-22 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1592839379432-PCCLAZYFJGFW8A0L0TFA/giardia-banner.jpg researcharticles - Lifting the lid on toilet plume aerosol: A literature review with suggestions for future research https://erinjengelsonphd.com/researcharticles/coupling-polar-adhesion-with-traction-spring-and-torque-forces-allows-high-speed-helical-migration-of-the-protozoan-parasite-toxoplasma monthly 0.5 2020-06-19 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1592516206519-5S6MGY3NGFNWS2ZCU25M/nn0c01893_0008+Toxo+plas+2020+June.gif researcharticles - Coupling Polar Adhesion with Traction, Spring, and Torque Forces Allows High-Speed Helical Migration of the Protozoan Parasite Toxoplasma https://erinjengelsonphd.com/researcharticles/molecular-dissection-of-chagas-induced-cardiomyopathy-reveals-central-disease-associated-and-druggable-signaling-pathways monthly 0.5 2020-06-16 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1592333768566-6PMEXDV7333N89290E2O/journal.pntd.0007980.g002+Chagas+Drugs.PNG researcharticles - Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways https://erinjengelsonphd.com/researcharticles/age-sex-and-disease-specific-associations-between-resting-heart-rate-and-cardiovascular-mortality-in-the-uk-biobank monthly 0.5 2020-06-10 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1591748245028-T9IPHTDGBSY0H81PPYY4/journal.pone.0233898.g001+Figure+1+resting+heart+rate.PNG researcharticles - Age, sex and disease-specific associations between resting heart rate and cardiovascular mortality in the UK BIOBANK https://erinjengelsonphd.com/researcharticles/airway-mir-155-responses-are-associated-with-th1-cytokine-polarization-in-young-children-with-viral-respiratory-infections monthly 0.5 2020-06-08 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1591586742076-ALSE5UMCZN75EF7JATAG/RSV+journal.pone.0233352.g001.PNG researcharticles - Airway mir-155 responses are associated with TH1 cytokine polarization in young children with viral respiratory infections https://erinjengelsonphd.com/researcharticles/time-series-modelling-to-forecast-the-confirmed-and-recovered-cases-of-covid-19 monthly 0.5 2020-06-07 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1591558839851-D5U0TILVPAA3MOFYH2JQ/Recovered+cases+COVID+through+April+2020.jpg researcharticles - Time series modelling to forecast the confirmed and recovered cases of COVID-19 https://erinjengelsonphd.com/researcharticles/on-setting-expectations-for-a-sars-cov-2-vaccine monthly 0.5 2020-06-06 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1591455206909-C2RC781LTWFXHQP19CHU/SARS+COV2+Vaccine.jpg researcharticles - On setting expectations for a SARS-CoV-2 Vaccine https://erinjengelsonphd.com/researcharticles/the-impact-of-ethnicity-on-clinical-outcomes-in-covid-19-a-systematic-review monthly 0.5 2020-06-04 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1591242999656-0ADZ0HD3D8IXEPVUY09V/dupont_hospital_delaware_national_guard_coronavirus_01_042420-768x548.jpg researcharticles - The impact of ethnicity on clinical outcomes in COVID-19: A systematic review https://erinjengelsonphd.com/researcharticles/a-strategic-approach-to-covid-19-vaccine-rampd monthly 0.5 2020-05-31 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1590905114152-NFDX9M2SAVTAMDKR0MHU/F2.large.jpg researcharticles - Introductions and early spread of SARS-CoV-2 in the New York City area https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1590903837584-8PQ549H4HDAI7L5UHEJG/F1.large+%282%29.jpg researcharticles - Introductions and early spread of SARS-CoV-2 in the New York City area https://erinjengelsonphd.com/researcharticles/rapid-repurposing-of-drugs-for-covid-19 monthly 0.5 2020-05-30 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1590877407547-GUUT1GEPTR9XF4T9OPJT/02-covid-spotlight-invivogen.png researcharticles - Rapid repurposing of drugs for COVID-19 https://erinjengelsonphd.com/researcharticles/tched40irzk85s4ds4fc6evljccedj monthly 0.5 2020-05-30 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1590725475859-7XDT5KFGC2F45ZQN41YP/PUJY4PLZ2HTKWTLUWBHQV3CS7M+Getty+image+Scott+Eisen.jpg researcharticles - Excess mortality in men and women in Massachusetts during the COVID-19 pandemic. https://erinjengelsonphd.com/researcharticles/safety-tolerability-and-immunogenicity-of-a-recombinant-adenovirus-type-5-vectored-covid-19-vaccine-a-dose-escalation-open-label-non-randomised-first-in-human-trial monthly 0.5 2020-05-28 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1590190670581-RY5NTS637JIRR30TZSCG/gr1+T+cells.jpg researcharticles - Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial https://erinjengelsonphd.com/researcharticles/mount-st-helens-at-40 monthly 0.5 2020-05-19 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1589867965462-UWKR2YFAPOOGUJ4B1FO7/image-asset.jpeg researcharticles - Mount St. Helens at 40 https://erinjengelsonphd.com/researcharticles/coronavirus-pandemic-in-the-us-6AFbk monthly 0.5 2020-05-19 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1589867056498-S035M5Q9ZP0O38AW4140/Proposed-host-immune-responses-during-SARS-CoV-2-infection-Aerosolized-uptake-of.png researcharticles - Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic https://erinjengelsonphd.com/researcharticles/screening-of-healthcare-workers-for-sars-cov-2-highlights-the-role-of-asymptomatic-carriage-in-covid-19-transmission monthly 0.5 2020-05-14 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1589411061408-9S3WAO3OU8BT6PL3QJ2L/Aldebrook+Cambridge+Hospitals.jpg researcharticles - 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Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/dc1f6a7d-bbe0-4863-99c3-32893e432e74/sciimmunol.add4906-f1.jpg New in SARS-CoV-2 - Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://erinjengelsonphd.com/sars-cov-2-new/as-omicron-rages-on-scientists-have-no-idea-what-comes-next monthly 0.5 2022-07-27 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/973cdc04-89df-4501-af42-dd6f946d401a/_20220722_nid_sars_evolution.jpg New in SARS-CoV-2 - As Omicron rages on, scientists have no idea what comes next - Make it stand out A nurse prepares a COVID-19 vaccine in Guwahati, India, on 10 April. A new subvariant named BA.2.75 that was first detected in India has surfaced in many other countries. ANUPAM NATH/AP IMAGES https://erinjengelsonphd.com/sars-cov-2-new/the-molecular-epidemiology-of-multiple-zoonotic-origins-of-sars-cov-2 monthly 0.5 2022-07-27 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/4ed79972-7f44-47f1-85f3-d78044144d2c/science.abp8337-f1.jpg New in SARS-CoV-2 - The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://erinjengelsonphd.com/sars-cov-2-new/safety-immunogenicity-and-reactogenicity-of-bnt162b2-and-mrna-1273-covid-19-vaccines-given-as-fourth-dose-boosters monthly 0.5 2022-07-06 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/fbff7eef-9c87-4855-8747-64ac4b70eeb2/gr2_lrg.jpg New in SARS-CoV-2 - Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters - Make it stand out Figure 2 Solicited adverse events within 7 days following fourth-dose vaccination in participants who received a study vaccine (A) Severe (grade 3–4) local and systemic adverse events. (B) Moderate or severe (grade 2–4) local and systemic adverse events. For each solicited adverse event, the highest severity within the first 7 days after fourth-dose vaccination at an individual level was used to draw the plot. https://erinjengelsonphd.com/sars-cov-2-new/fda-authorizes-covid-vaccines-for-the-littlest-kids-what-the-data-say monthly 0.5 2022-06-20 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/f1ad51ac-b9ea-4751-8a9a-d69488bdaece/children+Nature+News+June+17+2022.jpg New in SARS-CoV-2 - FDA authorizes COVID vaccines for the littlest kids: what the data say - Make it stand out Kids under five years old are the largest group of people in the United States not yet eligible for COVID-19 vaccines. 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Credit: Majority World/Universal Images Group via Getty https://erinjengelsonphd.com/sars-cov-2-new/cebr-vaccines-and-related-biological-products-advisory-committee-meeting-june-14th-and-15th-2022 monthly 0.5 2022-06-27 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/608b580a-2611-4fbf-be08-3a0bb0674d5d/0619221916.jpg New in SARS-CoV-2 - CEBR Vaccines and Related Biological Products Advisory Committee meeting, June 14th and 15th, 2022 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://erinjengelsonphd.com/sars-cov-2-new/b11529-reported-in-vitro-therapeutic-activity-update-for-june-13-2022 monthly 0.5 2022-06-13 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/745b5fdf-3739-4c71-bd2b-a19dc7e6618e/Omicron+cropped+June+13+2022.jpg New in SARS-CoV-2 - B.1.1.529 Reported in vitro Therapeutic Activity, Update for June 13, 2022 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://erinjengelsonphd.com/sars-cov-2-new/sudden-rise-of-more-transmissible-form-of-omicron monthly 0.5 2022-02-04 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/d9c39849-5a3a-4e25-bd19-07361167bfdb/Trevor+Bedford+Tree+Jan+2022.jfif New in SARS-CoV-2 - Sudden rise of more transmissible form of Omicron - Make it stand out As this depiction of the SARS-CoV-2 evolutionary tree suggests, the BA.1 and BA.2 strains of the Omicron variant are about as genetically distinct as earlier variants Alpha, Beta, and Gamma are from each other. Diagram credit: https://nextstrain.org/ncov/gisaid/global https://erinjengelsonphd.com/sars-cov-2-new/new-omicron-data monthly 0.5 2022-06-13 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/6827d9c3-79c7-404b-a735-bd72fb8533c5/Screenshot+%2852%29.png New in SARS-CoV-2 - B.1.1.529 Reported In Vitro Therapeutic Activity, Update For January 5, 2022 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://erinjengelsonphd.com/sars-cov-2-new/a-new-tool-to-probe-sars-cov-2-variants monthly 0.5 2021-12-30 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/df74480c-f8bd-4f19-b95f-fda02c5a4013/White%2BLights.jpg New in SARS-CoV-2 - A new tool to probe SARS-CoV-2 variants - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://erinjengelsonphd.com/sars-cov-2-new/comirnaty-booster-doses monthly 0.5 2021-11-19 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/537258da-402d-4c51-ada4-7401f6a339c9/Comirnaty_thumb.jpg New in SARS-CoV-2 - 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Vaccines and Related Biological Products Advisory Committee Meeting October 26, 2021 Briefing Document - Make it stand out Scenario 4: COVID-19 incidence as of September 11, 2021, VE 90% vs. COVID-19 cases and 100% vs. COVID-19 hospitalization. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/74ded0a8-415b-4b20-a3d6-113e910a5465/Screen-Shot-2021-10-26-at-6.03.12-PM-1440x810.png New in SARS-CoV-2 - Vaccines and Related Biological Products Advisory Committee Meeting October 26, 2021 Briefing Document - Make it stand out Scenario 6: COVID-19 incidence as of September 11, 2021, VE 70% vs. COVID-19 cases and 80% vs. COVID-19 hospitalization, excess myocarditis cases 50% of Scenario 1. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/e7750858-074c-46df-b10e-6ba516b85cb7/Screen-Shot-2021-10-26-at-6.01.35-PM-640x358.png New in SARS-CoV-2 - Vaccines and Related Biological Products Advisory Committee Meeting October 26, 2021 Briefing Document - Make it stand out Scenario 1: COVID-19 incidence as of September 11, 2021, VE 70% vs. COVID-19 cases and 80% vs. COVID-19 hospitalization. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/fb226d06-2301-470f-be3c-11548d659fb8/Screen-Shot-2021-10-26-at-6.02.18-PM-1440x808.png New in SARS-CoV-2 - Vaccines and Related Biological Products Advisory Committee Meeting October 26, 2021 Briefing Document - Make it stand out Scenario 3: COVID-19 incidence as of nadir in June 2021, VE 70% vs. COVID-19 cases and 80% vs. COVID-19 hospitalization. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/5136d7c3-8783-47a0-a480-5a841a605c9f/Screen-Shot-2021-10-26-at-6.02.43-PM-1440x810.png New in SARS-CoV-2 - Vaccines and Related Biological Products Advisory Committee Meeting October 26, 2021 Briefing Document - Make it stand out Scenario 5: COVID-19 case incidence as of September 11, 2021, VE 70% vs. COVID-19 cases and 80% vs. COVID-19. hospitalization, COVID-19 death rate 300% that of Scenario 1. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/2090291c-eb58-4672-8182-cc0aad3ebf69/Screen-Shot-2021-10-26-at-6.04.47-PM-640x358.png New in SARS-CoV-2 - Vaccines and Related Biological Products Advisory Committee Meeting October 26, 2021 Briefing Document - Make it stand out Myocarditis risks by age and sex. https://erinjengelsonphd.com/sars-cov-2-new/6-month-neurological-and-psychiatric-outcomes-in-236379-survivors-of-covid-19-a-retrospective-cohort-study-using-electronic-health-records monthly 0.5 2021-04-08 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1617827722698-ASMTO5B92V8PCWAVG3XU/gr1.jpg New in SARS-CoV-2 - 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records Figure 1 Kaplan-Meier estimates for the incidence of major outcomes after COVID-19 compared with other RTIs Shaded areas are 95% CIs. For incidences of first diagnoses, the number in brackets corresponds to all patients who did not have the outcome before the follow-up period. For diagnostic subcategories, see appendix (pp 8–10). RTI=respiratory tract infection. https://erinjengelsonphd.com/astoriastemacademy daily 0.75 2024-06-11 https://erinjengelsonphd.com/astoriastemacademy/introducing-stem-astoria-day-camp monthly 0.5 2025-11-11 https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/54cc348d-f008-4838-85aa-e242f573bc39/Microscopes+and+Biological+Slide+Lesson+Ripley+Winter+2022.jpg Astoria STEM Academy - Astoria STEM Academy, Founded in 2021 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/64fd5b55-3933-4d7d-94b7-f74803cf8b35/Gal%27s+STEM+Night+Soap%2C+February+14%2C+2022.jpg Astoria STEM Academy - Astoria STEM Academy, Founded in 2021 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5e9a4d68ac7d5a52ec5b6510/1998bd8e-0027-4a26-85c0-18218166c524/STEM.AA_color.png Astoria STEM Academy - 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Oregon Department Of Education: Standards For Grade 3 - Make it stand out These floodgates in Venice are an example of a design solution that reduces the impact of weather events. 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